It means I lost. Everything.

[There is no exaggeration in what he's saying. Everything is gone for him now, even the last two people who wanted to get him out.]

I asked Michael to stop, and he wouldn't. And then Castiel- he killed Raphael for trying to get us out of the Cage. And now, the only demon who could have freed me again is strung up on the racks.

[His voice falls lower, barely audible.]

I am never getting out.